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picto pharmimage 2Chi-mice®

Use our humanized models to select your drug candidates effectively

Chi-Mice® is Oncodesign’s dedicated technology for the development of humanized preclinical models. It is the best possible tool for evaluating new therapeutic approaches in conditions as comparable as possible to a clinical situation:

  • Over 250 patient-derived xenografts (PDX) to date, combined with their pharmacological, histological, genomic, molecular and clinical profile accessible in a database
  • Murine models featuring humanized tissue from human stem cells: human immune system, human liver, human epithelial cells, human fibroblasts, human skin graft, microbiome
  • Transgenic models
  • Expertise in a broad panel of murine strains: NSG, BRGS, NSG-SGM3, NOG, Nude, SCID, immuno-competent, etc., plus Nude and immuno-competent rats
  • Sample biobank: histological slides, serum of tumor-bearing murine models, RNA and DNA extracts, cell rows derived from in vivo models, tumor stem cells and healthy tissues, patient clinical data.

The technology is predicated on an international network of researchers and clinicians, and the collection of healthy biological samples or voluntary patients, including for rare diseases in accordance with ethical regulations.

Applications:

  • Anti-tumor efficacy of small molecules and immunotherapies
  • In vivo ADCC effect
  • Toxicology
  • Transplantation
  • Infectious diseases
  • Inflammation
  • Autoimmune diseases
  • Stem cells
  • Determination of biomarkers
  • Innate and acquired immunity
  • Hematopoiesis
  • Vaccine development
  • Etc.

Chi-Mice® continues to expand thanks to the developments carried out in IMODI personalized medicine.

Are you interested? Do you want to know more or receive our up-to-date list of models for a specific indication? Contact us today.