A portfolio of validated animal models covering the spectrum of liver inflammation diseases to support R&D

A portfolio of validated animal models covering the spectrum of liver inflammation diseases to support R&D

 

Spotlight on inflammatory diseases: live from our experts

Dedicated FREE webinar on preclinical liver diseases models

Liver inflammation-related disorders

Liver is the largest solid organ in our body. It is responsible for filtering blood coming from the digestive tract, and it plays a central role in the metabolism of lipids, glucose and drugs. Acute and chronic liver pathologies can lead to defective liver function and life-threatening conditions.

Liver inflammation represents a key contributor to pathology during both acute and chronic liver injury. Although mild inflammatory responses have been shown to promote protective effects, contributing to tissue repair and promoting the re-establishment of liver homeostasis, excessive inflammation may lead to massive hepatocyte loss and hence exacerbate the severity of various hepatic conditions.

Liver immune cell dysregulation is critical in the pathogenesis of most types of liver diseases including viral hepatitis, autoimmune hepatitis, fatty liver, alcoholic liver diseases, cirrhosis, and drug/toxin-induced injury. Prospective comprehension of liver inflammation therefore improves the understanding of the underlying immune mechanisms causing liver damage as well as liver repair after damage.

Solutions for the validation of new therapeutic strategies

The clinical management of liver diseases encompasses treatment of the underlying cause of the pathology – e.g. virus elimination, alcohol deprivation, dietary change and exercise, immune-suppression – as well as use of new therapeutic areas such as hepatoprotectants, immune-therapies, or drugs acting on inflammation and fibrosis.

Distinct from in vitro cell culture systems, experimental animal models enable to study cell biology in a complex system, including whole organs and the crosstalks between them, within living organisms. Thus animal models offer opportunities to study biological, pathological, and histological characteristics of human liver diseases and provide a useful platform for developing novel therapeutic approaches and testing new drugs. No animal model entirely recapitulates the human disease animal but several have been identified to simulate the disease.

At Oncodesign, our highly experienced team pays particular attention to guide our clients to select the most appropriate models to design experiments suitable for the objective of the studies.

Oncodesign’s team has established a variety of animal models for liver disease models covering the progression of liver diseasesfrom acute liver injury to fibrosis and cancer models. Our collection of preclinical models provides a large spectrum of possibilities to explore specific aspects of liver disease progression including metabolic disordersinflammation and fibrosis and evaluate innovative therapeutic strategies.

Preclinical models of liver disease available at Oncodesign

Liver is the largest solid organ in our body. It is responsible for filtering blood coming from the digestive tract, and it plays a central role in the metabolism of lipids, glucose and drugs.

Inflammation - preclinical liver diseases models

Invalid Input

Invalid Input

Invalid Input

your address is not a proper one. Please check.

Invalid Input

We care about your privacy.
Since you are a valuable customer or prospect, we want to make sure that you can choose to stay connected with Oncodesign. Oncodesign collectgs your data to provide you with information regarding our offering and news.
In accordance with the law "Informatique et Libertés", you can exercise your right of access to the data concerning you and have them rectified by contacting odsmarketing@oncodesign.com.
Your Email address has not been and will not be given to third parties. 

Oncodesign is registered with CNIL under number 2102182.

I become an expert

Do not miss out our FREE WEBINAR about liver disease and the preclinical models available to mimic human pathologies to predict your drug efficacy.

Our expert teams are available to discuss your projects to find the best of our options to accelerate your drug discovery phases.